Career Opportunities
If you would like to advertise a position then please contact IBIN@kcl.ac.uk
Research Associate for DiSPIM Imaging and Analysis
King’s College London
Location: London, UK
Full time: Yes
Salary: £38,826 – £42,087, including London Weighting Allowance
Closing date: 07-Dec-2021
This is an exciting opportunity to join a large team working on a Wellcome Leap project to understand tissue state evolution of time in triple negative breast cancer patients. The post holder will perform a critical function in performing long-term imaging using advanced microscopy approaches to quantify organoid and tissue responses to chemotherapy. The post holder will develop post-acquisition analysis pipelines to enable accurate quantification of cell and tissue phenotypes over time and assist with integration of these datasets with data retrieved from other imaging modalities. The post holder will work with a large inter-disciplinary team both at King’s and with our global partners to deliver new insight into TNBC tumour progression and help identify novel biomarkers for personalised medicine approaches.
Find out more and apply here.
Research Associate for DiSPIM Imaging and Analysis
King’s College London
Location: London, UK
Full time: Yes
Salary: £38,826 – £42,087, including London Weighting Allowance
Closing date: 10-Oct-2021
This is an exciting opportunity to join a large team working on a Wellcome Leap project to understand tissue state evolution of time in triple negative breast cancer patients. The post holder will perform a critical function in performing long-term imaging using advanced microscopy approaches to quantify organoid and tissue responses to chemotherapy. The post holder will develop post-acquisition analysis pipelines to enable accurate quantification of cell and tissue phenotypes over time and assist with integration of these datasets with data retrieved from other imaging modalities. The post holder will work with a large inter-disciplinary team both at King’s and with our global partners to deliver new insight into TNBC tumour progression and help identify novel biomarkers for personalised medicine approaches.
Find out more and apply here.
If you would like to advertise a position then please contact IBIN@kcl.ac.uk
Post-Doctoral Research Associate in Comprehensive Cancer Centre
King’s College London
Location: London, UK
Full time: Yes, Fixed-term for up to 3 years
Salary:£38,304 – £ 45,026, including London Weighting Allowance
Closing date: 16-Aug-2021
We are seeking a highly motivated and talented postdoctoral researcher to join Dr. Simon Poland’s advanced microscopy development group at the Comprehensive Cancer Centre at King’s College London. The overall goal of this research project is to develop novel imaging strategies which will enable the complete interrogation of tumour derived spheroid models. The successful candidate will design and develop advanced light sheet microscopy instrumentation to acquire aberration-free images and functional information of large 3D cell culture models non-invasively, at high-speed and at high resolution. They will collaborate with several cancer research scientists at King’s, where this technology will then be exploited to image tumour spheroid cultures and investigate several key interactions between cancer cells, other constituent cells and the extracellular matrix in the tumour microenvironment.
Find out more and apply here.
Advanced Imaging Specialist
University of Birmingham
Location: Birmingham, UK
Full time: Yes, Fixed-term
Salary: £30,942 to £40,322 with potential progression once in post to £42,792 a year
Closing date: 11th June 2021
Centre of Membrane Proteins and Receptors (COMPARE), College of Medical and Dental Sciences
We are seeking a highly motivated lead Imaging Specialist to join our vibrant, multidisciplinary team at the Centre of Membrane Proteins and Receptors (COMPARE) of the University of Birmingham (UK). COMPARE, a joint venture with the University of Nottingham, brings together world-leading experts in microscopy, biophysics and computer science to investigate the fundamental mechanisms of receptor signalling and their alterations in human disease. Our Advanced Microscopy Facility hosts 9 state-of-the art fluorescence microscopes (lattice light sheet, Marianas diSPIM, Ultramicroscope II, Nikon N-STORM, 4-camera TIRF, ultrafast FRET/calcium imaging, Nikon N-SIM, FCS, and two-photon) plus several custom experimental set-ups. The lead Imaging Specialist is a key role in COMPARE, taking responsibility for the management and day-to-day running of the Advanced Microscopy Facility, ensuring maintenance of the equipment and providing training and support to a wide user base. Working with the COMPARE Image Analysis Specialist, they provide comprehensive advice on experimental design, image acquisition and data analysis. Successful candidates should hold a Ph.D. or equivalent degree in Biology, Biophysics, Optical Engineering, or related field. They will have a firm background in cell biology and fluorescence microscopy, expert knowledge of the most common fluorescence microscopy techniques and hands-on experience on imaging biological samples along with expertise in image processing and analysis (ImageJ, Arivis, MATLAB, etc). Previous experience with running and/or working in a multiuser fluorescence microscopy facility is strongly preferred. Excellent organisational and communication skills, the ability to work as part of a team and a willingness to help users are essential.
Main Duties and Responsibilities:
Maintain the microscopes in the COMPARE Advanced Microscopy Facility.
Develop research objectives and proposals for use of the range of specialist microscopes, including advising graduate students, postdoctoral and PIs on the right microscope for each purpose.
Training of all individuals who wish to use the microscopes.
Qualifications, Skills and Knowledge:
First degree in area of specialism and normally, a higher degree relevant to research area or equivalent qualifications.
Fluency in relevant models, techniques or methods and ability to contribute to developing new ones.
Informal enquires can be made to Professor Davide Calebiro, COMPARE Director, at d.calebiro@bham.ac.uk
To download the full job description and details of this position and submit an electronic application online please visit https://www.birmingham.ac.uk/staff/jobs/index.aspx Please quote Job Ref 56353 in all enquiries.
Research Associate
University of Bath
Location: bath, UK
Full time: Yes, Fixed-term, 1 year
Salary: Starting from £33,797, rising to £40,322
Closing date: Thursday 04 February 2021
Spectroscopic imaging to assess drug pharmacokinetics in the skin
The central hypothesis of the research is that Raman spectroscopic imaging can provide a minimally invasive, accurate, sensitive, reproducible and at least semi-quantitative determination of the rate and extent to which a topically administered drug becomes available at its site of action in the skin (and, specifically, the epidermis). The principal goal is to develop experimental methods – specifically, mass spectroscopic tools such as SIMS and MALDI – to test this hypothesis ex vivo. The project combines existing know-how in the assessment of topical bioavailability with a novel spectroscopic imaging strategy to explore whether the routine, facile and non-invasive measurement of drug pharmacokinetics in the skin is an attainable objective with potential for application in regulatory science and decision-making.
The specific responsibilities of the role include:
Using Raman imaging to (semi-) quantitatively measure a drug’s “input kinetics” into the epidermis.
Validation of Raman imaging with mass spectroscopic tools to quantify drug input kinetics into the epidermis.
Data processing, analysis and interpretation.
You should have first-hand experience of the biophysical applications of Raman and mass spectroscopic imaging methods and knowledge of the pharmaceutical sciences underpinning drug delivery across biological barriers. You will perform a significant portion of the research with collaborators at the National Physical Laboratory (Teddington, UK).
This position is fixed-term for up to 12 months.
Informal enquiries should be addressed to Prof. Richard H. Guy (r.h.guy@bath.ac.uk), however, all applications, including a full CV and a list of publications/presentations, should be submitted via the University website.
Find out more and apply here.
Two Postdoctoral Scientist Positions
Alderley Park
Location: Cheshire, UK
Full time: Yes, Fixed-term, 1 year
We are advertising two Postdoctoral Scientist positions at Medicines Discovery Catapult
We have recently established our Advanced Light Microscopy facility which includes Super Resolution and Confocal/Multiphoton instruments and we are looking for motivated scientists to explore and apply imaging methods to answer cutting-edge medicines discovery questions. This is a chance for someone to join us at an exciting time when new application for medicines discovery are being developed and new research collaborative projects are being created around applying Single Molecule Localized Microscopy and Advanced light microscopy in the drug discovery field.
Two opportunities:
Postdoctoral Scientist – Advanced Microscopy
The role of Postdoctoral Scientist – Advanced Microscopy would suit a highly motivated self-starter who is passionate about the application of advanced light microscopy methods to medicines discovery. The successful candidate will bring a depth of expertise in advanced light microscopy and image analysis and will provide scientific input in this discipline to deliver collaborative projects and build new capabilities.
Through the application of a variety of advanced light microscopy methods, the candidate will characterise complex cell models and prosecute target validation and efficacy studies in support of externally partnered drug discovery projects. The individual will be an integral part of the microscopy team and will work closely with colleagues in interdisciplinary projects. The role will also involve collaboration with external partners, including medicine discovery companies, technology providers and academic institutes.
Find out more here.
Postdoctoral Scientist – Single Molecule Localization Microscopy
We are looking for a post-doctoral scientist with significant experience in Single Molecule Localization Microscopy (SMLM) to apply their expertise to new and cutting-edge questions in the drug discovery field, including cellular mechanism of action studies and biomarker analysis.
The successful individual will establish novel imaging methods & workflows utilizing the advanced imaging platform available at MDC and will apply them in collaborative projects with external partners, focussed on the discovery and development of small molecules and novel therapeutics. The project is a great opportunity to further develop SMLM applications and accelerate medicines discovery. The prospect to join a world class laboratory team in this high-profile national organisation should provide a fantastic platform for career development.
Find out more here.