Career Opportunities


 

 

If you would like to advertise a position then please contact IBIN@kcl.ac.uk

Research Associate

University of Bath

Location: bath, UK

Full time: Yes, Fixed-term, 1 year

Salary: Starting from £33,797, rising to £40,322

Closing date: Thursday 04 February 2021

 

Spectroscopic imaging to assess drug pharmacokinetics in the skin

The central hypothesis of the research is that Raman spectroscopic imaging can provide a minimally invasive, accurate, sensitive, reproducible and at least semi-quantitative determination of the rate and extent to which a topically administered drug becomes available at its site of action in the skin (and, specifically, the epidermis). The principal goal is to develop experimental methods – specifically, mass spectroscopic tools such as SIMS and MALDI – to test this hypothesis ex vivo. The project combines existing know-how in the assessment of topical bioavailability with a novel spectroscopic imaging strategy to explore whether the routine, facile and non-invasive measurement of drug pharmacokinetics in the skin is an attainable objective with potential for application in regulatory science and decision-making.

The specific responsibilities of the role include:

Using Raman imaging to (semi-) quantitatively measure a drug’s “input kinetics” into the epidermis.
Validation of Raman imaging with mass spectroscopic tools to quantify drug input kinetics into the epidermis.
Data processing, analysis and interpretation.
You should have first-hand experience of the biophysical applications of Raman and mass spectroscopic imaging methods and knowledge of the pharmaceutical sciences underpinning drug delivery across biological barriers. You will perform a significant portion of the research with collaborators at the National Physical Laboratory (Teddington, UK).

This position is fixed-term for up to 12 months.

Informal enquiries should be addressed to Prof. Richard H. Guy (r.h.guy@bath.ac.uk), however, all applications, including a full CV and a list of publications/presentations, should be submitted via the University website.

Find out more and apply here.

 

 

Two Postdoctoral Scientist Positions

Alderley Park

Location: Cheshire, UK

Full time: Yes, Fixed-term, 1 year

 

We are advertising two Postdoctoral Scientist positions at Medicines Discovery Catapult

We have recently established our Advanced Light Microscopy facility which includes Super Resolution and Confocal/Multiphoton instruments and we are looking for motivated scientists to explore and apply imaging methods to answer cutting-edge medicines discovery questions. This is a chance for someone to join us at an exciting time when new application for medicines discovery are being developed and new research collaborative projects are being created around applying Single Molecule Localized Microscopy and Advanced light microscopy in the drug discovery field.

 

Two opportunities:

Postdoctoral Scientist – Advanced Microscopy

The role of Postdoctoral Scientist – Advanced Microscopy would suit a highly motivated self-starter who is passionate about the application of advanced light microscopy methods to medicines discovery. The successful candidate will bring a depth of expertise in advanced light microscopy and image analysis and will provide scientific input in this discipline to deliver collaborative projects and build new capabilities.

Through the application of a variety of advanced light microscopy methods, the candidate will characterise complex cell models and prosecute target validation and efficacy studies in support of externally partnered drug discovery projects. The individual will be an integral part of the microscopy team and will work closely with colleagues in interdisciplinary projects. The role will also involve collaboration with external partners, including medicine discovery companies, technology providers and academic institutes.

Find out more here.

 

Postdoctoral Scientist – Single Molecule Localization Microscopy

We are looking for a post-doctoral scientist with significant experience in Single Molecule Localization Microscopy (SMLM) to apply their expertise to new and cutting-edge questions in the drug discovery field, including cellular mechanism of action studies and biomarker analysis.

The successful individual will establish novel imaging methods & workflows utilizing the advanced imaging platform available at MDC and will apply them in collaborative projects with external partners, focussed on the discovery and development of small molecules and novel therapeutics. The project is a great opportunity to further develop SMLM applications and accelerate medicines discovery. The prospect to join a world class laboratory team in this high-profile national organisation should provide a fantastic platform for career development.

Find out more here.